This book is written for the pharmacokineticist who performs pharmacokinetic-pharmacodynamic modeling and is occasionally asked to model data that may have nothing to do with pharmacokinetics, but may be important in other areas of drug development. The emphasis of this book is on modeling in drug development since that is my own area of expertise and because ultimately all pharmacokinetic-pharmacodynamic modeling is applied to the therapeutic use of drugs in clinical practice. Throughout this book, pharmacokinetic and pharmacodynamic models will be used without derivation and little in the way of explanation. It is expected the reader has basic knowledge of pharmacokinetics and simple pharmacodynamic models

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