11:47 PM
The chapters in this book can be broadly categorized into four major themes: Global regulatory processes (Chapters 2, 4, 5, and 7): This section provides a regulatory perspective and reviews existing global regulatory processes . It also proposes new and innovative ways for regulatory review of excipients, which, if adopted, should promote innovation. This section also provides a status update on the global compendial harmonization, which should eliminate non–value-added testing that manufacturers and users of excipients currently have to perform. Preclinical testing and development and development of new and coprocessed excipients (Chapters 3, 6, 9, and 20): This section describes the type of preclinical testing that is required in support of the development and registration of new excipients and presents a case study for successful development of a novel excipient. Lastly, Chapter 20 looks to the future and identifies excipients needed for innovative biotechnologically derived dosage forms. (read more) or download here
11:37 PM
The manufacture and control of oral solutions and oral
suspensions presents some unusual problems not common
to other dosage forms. Although bioequivalency concerns
are minimal (except for products in which dissolution is
a rate-limiting or absorption-determining step, as in
phenytoin suspension), other issues have frequently led to
recalls of liquid products. These include microbiological,
potency, and stability problems. In addition, because the
population using these oral dosage forms includes newborns,
pediatrics, and geriatrics, who may not be able to
take oral solid dosage forms and who may have compromised
drug metabolic or other clearance function, defective
dosage forms can pose a greater risk if the absorption
profiles are significantly altered from the profiles used in
the development of drug safety profiles. (read more) or
download here
READ MORE - Handbook of Pharmaceutical Manufacturing Formulations Liquid Products (Volume 3 of 6)suspensions presents some unusual problems not common
to other dosage forms. Although bioequivalency concerns
are minimal (except for products in which dissolution is
a rate-limiting or absorption-determining step, as in
phenytoin suspension), other issues have frequently led to
recalls of liquid products. These include microbiological,
potency, and stability problems. In addition, because the
population using these oral dosage forms includes newborns,
pediatrics, and geriatrics, who may not be able to
take oral solid dosage forms and who may have compromised
drug metabolic or other clearance function, defective
dosage forms can pose a greater risk if the absorption
profiles are significantly altered from the profiles used in
the development of drug safety profiles. (read more) or
download here
11:27 PM
Nernst and Zeta Potentials
1:26 AM
1:07 AM
In March 2001, the National Institutes of Health issued the following warning: "The number of Web sites offering health-related resources grows every day. Many sites provide valuable information, while others may have information that is unreliable or misleading."1 Furthermore, because of the rapid increase in Internet-based information, many hours can be wasted searching, selecting, and printing. Since only the smallest fraction of information dealing with herbal medicine is indexed in search engines, such as www.google.com or others, a non-systematic approach to Internet research can be not only time consuming, but also incomplete. This book was created for medical professionals, students, and members of the general public who want to know as much as possible about herbal medicine, using the most advanced research tools available and spending the least amount of time doing so. Read more or download here
12:56 AM
History of PharmacologySince time immemorial, medicaments have been used for treating disease in
humans and animals. The herbals of antiquity describe the therapeutic powers of certain plants and minerals. Belief in the curative powers of plants and certain substances rested exclusively upon traditional knowledge, that is, empirical information not subjected to critical examination.
Read more or Download here
humans and animals. The herbals of antiquity describe the therapeutic powers of certain plants and minerals. Belief in the curative powers of plants and certain substances rested exclusively upon traditional knowledge, that is, empirical information not subjected to critical examination.
Read more or Download here
12:01 AM
Sample preparation is important in all aspects of chemical, biological, materials, and surface analysis. Notable among recent developments are faster, greener extraction methods and microextraction techniques. Specialized sample preparations, such as self-assembly of analytes on nanoparticles for surface enhancement, have also evolved. Developments in highthroughput workstations for faster preparation–analysis of a large number of samples are impressive. These use 96-well plates (moving toward 384 wells) and robotics to process hundreds of samples per day, and have revolutionized research in the pharmaceutical industry. Advanced microfabrication techniques have resulted in the development of miniaturized chemical analysis systems that include microscale sample preparation on a chip. Considering all these, sample preparation has evolved to be a separate discipline within the analytical/measurement sciences. (read more) or (download here)
8:55 AM
untuk alasan analisis farmasi khususnya farmakokinetika, kebutuhan akan Kertas grafik linear inch, linear metric, semi log merupakan kebutuhan "primer" bagi seorang farmasist. so! teman-teman silahkan download disini
READ MORE - Graphic Paper8:44 AM
In this book, we define "pharmaceuticals" as drug substances having pharmacological effects and the dosage forms containing these drug substances, which are intended for therapeutic use. Drug substances used at the present time range from small-molecular-weight chemicals to polymers such as proteins. In the future, products derived from genomic research will have to be included. Some drug substances are susceptible to chemical degradation under various conditions owing to their fragility of their molecular structure. Other drug substances undergo physical degradation changes rather than chemical degradation, leading to various changes in their physical state. Download disini
